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Joined 9 months ago
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Cake day: February 8th, 2024

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  • So do I understand correctly that a certain hox gene is activated in basically all cells which are in the “domain” of a certain vertebrae and they all activate some subset of homeobox genes which in combination with the original hox gene cause them to start turning into all the different parts associated with that vertebrae (so organs and other structures)?

    Would we then need an entirely new hox gene to produce even a single gill? (I know you basically just laid out most of a response to this question.) Because I would assume although the exact point at which the development of our arms and legs begins is part of the whole hox gene “superstructure”, but couldn’t we ‘basically just’ highjack this same system and duplicate this gene to produce at least a single gill in the region where the current hox gene for our neck is expressed?

    Long story short: what is the biggest reason why we can’t just hack into a later part of the sequence and continue on from there with what you said?

    Or would your proposed plan also just end up like this in the final product and you laid it out like this because it’s already the most viable route into this mess? 😅


  • And that’s the thing:

    Assuming it did, you couldn’t see it approach until it hit you because it’s moving at the speed of light! It could also have happened, but just super far away such that it will never reach us due to expansion between its origin point and us being faster than c!

    Also just because the universe is frickin old doesn’t mean it is statistically bound to have happened. There are plenty of ways of making it even more astronomically unlikely but still possible…











  • Welcome to Greece! No, not our modern Greece, the old timey write philosophical questions into the dirt with sticks and argue with your best homies about it kind of Greece!

    Want to compute something? Hope you got all your steps in linear order so you don’t have to remember too much in between other steps!

    /s (but not really so I totally am on your side, original formulations of math problems are a pain…)






  • Uff this started out for me as being “easy! Minecraft, Factorio and a third one!”

    And then quickly and only devolved into an abyss of deliberation…

    • Do I take EU4+DLC+Anbennar because then I would finally have an excuse to actually learn and play this damn game? (Plus having base game and Anbennar basically doubles the replayability)
    • Do I take VintageStory so I can finally learn to actually play it well and start creating meaningful mods for it?
    • Should I take Noita or Caves of Qud? Should they be replacements for DF?
    • Is either of Civ V or Civ VI replayable about for me for this much time?

    And from there the more basic questions:

    • Does any of the three games need to be entertaining enough to basically always run or could/should it suffice to simply rotate between them?
    • How much time would I reasonably want to spend playing vs creating?
    • Also am I allowed to spend some time basically daydreaming every day (aka the games are meant more to actually keep me sane rather than get people to recommend good games they have given thought and time to?) or should they/would I want them to keep me occupied basically 15/7?

    So yeah, Minecraft probably still stands as there are way too many mods and building ideas for it to (probably?) become truly stale in a lifetime!

    And Factorio because I still want to actually finish an AB run for once, or a SE run, or … You get the idea. Buut the third slot would likely be a make or break for this whole endeavor and now it’s back to square one again!